Table 1.
Distribution of Selected Characteristics/Serotypes Among IPD Cases by Age and Risk Group, SIIPA, France, 2014–2017
| Characteristic | Category | Total (n = 908) | 18–64 y (n = 321) | 65+ y (n = 587) | P | High Risk (n = 335) | At Risk (n = 429) | Healthy (n = 144) | P | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | ||||
| Age groups, y | 18–49 | 140 | 16 | - | - | - | - | - | 38 | 11 | 63 | 15 | 39 | 27 | <.001 |
| 50–64 | 181 | 20 | - | - | - | - | - | 74 | 22 | 83 | 19 | 24 | 17 | ||
| 65–84 | 391 | 43 | - | - | - | - | - | 171 | 51 | 169 | 39 | 51 | 35 | ||
| 85+ | 196 | 22 | - | - | - | - | - | 52 | 16 | 114 | 27 | 30 | 21 | ||
| Residence | Institution | 121 | 13 | 15 | 5 | 106 | 18 | <.001 | 34 | 10 | 40 | 17 | 17 | 11 | .035 |
| Hospitalization in year 1 | Yes | 368 | 41 | 115 | 36 | 253 | 44 | .036 | 197 | 59 | 150 | 35 | 21 | 15 | <.001 |
| Severe diseaseb | Yes | 431 | 48 | 155 | 49 | 276 | 47 | .401 | 159 | 48 | 215 | 50 | 57 | 40 | .305 |
| Severe sepsis | Yes | 341 | 38 | 125 | 39 | 216 | 37 | .536 | 131 | 39 | 172 | 40 | 38 | 26 | .010 |
| Shock | Yes | 169 | 19 | 79 | 25 | 90 | 15 | <.001 | 50 | 15 | 102 | 24 | 17 | 12 | <.001 |
| Mechanical ventilation | Yes | 190 | 21 | 83 | 26 | 107 | 18 | .007 | 58 | 17 | 106 | 25 | 26 | 18 | .030 |
| ICU admission | Yes | 278 | 31 | 124 | 39 | 154 | 26 | <.001 | 97 | 30 | 144 | 36 | 37 | 26 | .192 |
| No. of at-risk conditions | 1–2 | 485 | 53 | 81 | 32 | 151 | 39 | <.001 | 164 | 49 | 321 | 75 | 0 | 0 | <.001 |
| (excl. smoking & alcoholism) | >2 | 279 | 31 | 40 | 16 | 140 | 36 | - | 171 | 51 | 108 | 25 | 0 | 0 | - |
| Site of infection | Pneumonia | 669 | 74 | 228 | 71 | 441 | 75 | .432 | 231 | 69 | 320 | 75 | 118 | 82 | <.001 |
| Pleuritis & pn. | 67 | 7 | 23 | 7 | 44 | 8 | - | 22 | 7 | 40 | 9 | 5 | 4 | ||
| Unkn/other | 172 | 19 | 70 | 22 | 102 | 17 | - | 82 | 25 | 69 | 16 | 21 | 15 | ||
| Chronic lung disease | Yes | 187 | 21 | 54 | 17 | 133 | 23 | .038 | 66 | 20 | 121 | 28 | 0 | 0 | <.001 |
| Smoking (current) | Yes | 166 | 18 | 121 | 38 | 45 | 8 | <.001 | 47 | 14 | 119 | 28 | 0 | 0 | <.001 |
| Heart failure | Yes | 165 | 18 | 14 | 4 | 151 | 26 | <.001 | 53 | 16 | 112 | 26 | 0 | 0 | <.001 |
| Diabetes mellitus | Yes | 166 | 18 | 30 | 9 | 136 | 23 | <.001 | 66 | 20 | 100 | 23 | 0 | 0 | <.001 |
| Malnutrition | Yes | 125 | 14 | 33 | 10 | 92 | 16 | .024 | 65 | 19 | 60 | 14 | 0 | 0 | <.001 |
| Alcoholism | Yes | 115 | 13 | 79 | 25 | 36 | 6 | <.001 | 26 | 8 | 89 | 21 | 0 | 0 | <.001 |
| Malignant solid tumors (<5 y) | Yes | 156 | 17 | 49 | 15 | 107 | 18 | .258 | 156 | 47 | 0 | 0 | 0 | 0 | - |
| Hematologic cancer (<5 y) | Yes | 116 | 13 | 28 | 9 | 88 | 15 | .231 | 116 | 35 | 0 | 0 | 0 | 0 | - |
| Immunosuppressive treatment | Yes | 92 | 10 | 43 | 13 | 49 | 8 | .016 | 92 | 28 | 0 | 0 | 0 | 0 | - |
| Vaccinated against: | Influenza | 215 | 26 | 39 | 13 | 176 | 33 | <.001 | 83 | 27 | 104 | 26 | 28 | 22 | .443 |
| Pneumococcus | 68 | 8 | 17 | 6 | 51 | 10 | .050 | 45 | 15 | 21 | 5 | 2 | 2 | <.001 | |
| Vaccinated with: | PCV7 | 2 | 0.2 | 1 | 0.3 | 1 | 0.2 | .677 | 1 | 0.3 | 1 | 0.3 | 0 | 0 | .815 |
| PCV13 | 29 | 4 | 8 | 4 | 21 | 4 | .343 | 22 | 7 | 7 | 2 | 0 | 0 | <.001 | |
| PPSV23 | 49 | 6 | 11 | 4 | 38 | 7 | .043 | 33 | 11 | 14 | 4 | 2 | 2 | <.001 | |
| Serotypes included in: | PCV7 | 42 | 5 | 16 | 5 | 26 | 5 | .007 | 19 | 6 | 19 | 5 | 4 | 3 | .002 |
| PCV13 only | 207 | 26 | 64 | 21 | 143 | 27 | - | 60 | 20 | 106 | 27 | 41 | 31 | - | |
| PPSV23 only | 353 | 42 | 150 | 50 | 203 | 38 | - | 118 | 39 | 174 | 44 | 61 | 46 | - | |
| Nonvaccine | 231 | 28 | 70 | 23 | 161 | 30 | - | 108 | 35 | 97 | 25 | 26 | 20 | - | |
| Individual serotypes | |||||||||||||||
| Other | 33 serotypes | 137 | 17 | 60 | 20 | 129 | 24 | .004 | 95 | 31 | 72 | 18 | 22 | 17 | <.001 |
| 3 | PCV13 | 123 | 15 | 38 | 13 | 85 | 7 | - | 36 | 12 | 69 | 17 | 18 | 14 | - |
| 8 | PPSV23 only | 77 | 9 | 38 | 13 | 39 | 7 | - | 14 | 5 | 51 | 13 | 12 | 9 | - |
| 22F | PPSV23 only | 63 | 8 | 22 | 7 | 41 | 8 | - | 21 | 7 | 32 | 8 | 10 | 8 | - |
| 19A | PCV13 | 55 | 7 | 42 | 8 | 13 | 4 | - | 18 | 6 | 25 | 6 | 12 | 9 | - |
| 12F | PPSV23 only | 50 | 6 | 24 | 5 | 26 | 9 | - | 8 | 3 | 26 | 7 | 16 | 12 | - |
| 9N | PPSV23 only | 49 | 6 | 28 | 5 | 21 | 7 | - | 17 | 6 | 21 | 5 | 11 | 8 | - |
| 15A | Nonvaccine | 38 | 5 | 25 | 5 | 13 | 4 | - | 21 | 7 | 11 | 3 | 6 | 5 | - |
| 24F | Nonvaccine | 29 | 4 | 19 | 4 | 10 | 3 | - | 9 | 3 | 13 | 3 | 7 | 5 | - |
| 11A | PPSV23 only | 28 | 3 | 17 | 3 | 11 | 4 | - | 13 | 4 | 11 | 3 | 4 | 3 | - |
| 20 | PPSV23 only | 25 | 3 | 13 | 2 | 12 | 4 | - | 8 | 3 | 13 | 3 | 4 | 3 | - |
| 23A | Nonvaccine | 24 | 3 | 15 | 3 | 9 | 3 | - | 8 | 3 | 13 | 3 | 3 | 2 | - |
| 10A | PPSV23 only | 21 | 3 | 10 | 2 | 11 | 4 | - | 12 | 4 | 7 | 2 | 2 | 2 | - |
| 19F | PCV13 | 21 | 3 | 11 | 2 | 10 | 3 | - | 7 | 2 | 12 | 3 | 2 | 2 | - |
| 6C | Nonvaccine | 21 | 3 | 19 | 4 | 2 | 0.7 | - | 6 | 2 | 12 | 3 | 3 | 2 | - |
| 35B | Nonvaccine | 20 | 2 | 16 | 3 | 4 | 1 | - | 12 | 4 | 8 | 2 | 0 | 0 | |
| Penicillin nonsusceptible | Yes | 166 | 20 | 51 | 17 | 115 | 22 | .112 | 83 | 27 | 58 | 15 | 25 | 19 | <.001 |
| Erythromycin nonsusceptible | Yes | 159 | 19 | 46 | 15 | 113 | 21 | .039 | 74 | 24 | 59 | 15 | 26 | 20 | .009 |
| Cefotaxime nonsusceptible | Yes | 28 | 3 | 19 | 4 | 9 | 3 | .664 | 14 | 5 | 11 | 3 | 3 | 2 | .314 |
Abbreviations: ICU, intensive care unit; IPD, invasive pneumococcal disease; PCV, pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine.