Table 3.

Number of Severe Cases Among Patients With Invasive Pneumococcal Disease by Selected Factors and Most Prevalent Serotypes, France, 2014–2017

Characteristic	Category	Severe Cases,a No.	%b	Risk Ratio	95% CI	Adjusted RR	95% CI
No. of comorbiditiesc	0	139	42	Ref	Ref	Ref	Ref
	1–2	243	51	1.2	1.0–1.4	1.2	1.0–1.4
	≥2	49	54	1.3	1.0–1.6	1.3	1.0–1.7
Serotype category	PCV13	148	60	1.5	1.3–1.9	1.6	1.3–1.9
	PPSV23nonPCV13	157	45	1.2	1.0–1.4	1.2	1.1–1.4
	Nonvaccine	90	39	Ref	Ref	Ref	Ref
Influenza vaccination	Yes	86	41	0.81	0.68–0.97	0.77	0.64–0.93
	No	301	50	Ref	Ref	Ref	Ref

Abbreviations: CI, confidence interval; IPD, invasive pneumococcal disease; PCV, pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine; RR, risk ratio.

^aSevere case = an IPD case with 1 of the following: ICU admission, shock or sepsis, or mechanical ventilation; risk = high-risk or at-risk case.

^bProportion of cases that were severe.

^cOne of the following comorbidities/conditions: heart disease, chronic lung disease, chronic liver disease, renal failure, chronic neurological disorder, diabetes mellitus, autoimmune disease, malnutrition, history of invasive pneumococcal disease, or pneumococcal pneumonia.