Table 1.

Common disproportionality analysis for safety signals

	Methods	Description	Signal score computation
Frequentist statistical methods	Proportional Reporting Ratio (PRR)	Statistical method to calculate the relative risk in order to measure the association strength for a drug-ADR pair	PRR05: lower bound of the 95% confidence interval of relative risk reporting ratio distribution
	Reporting Odds Ratio (ROR)	Statistical method to calculate the odds ratio in order to measure the association strength for a drug-ADR pair	ROR05: lower bound of the 95% confidence interval of odds ratio distribution
Bayesian-based methods	Multi-item Gamma Poisson Shrinker (MGPS)	Bayesian-based method to prevent false-positive signals from multiple comparisons. Generate an adjusted value based on Reporting Ratio (RR)	EB05: lower bound of the 95% of the posterior distribution for RR
	Bayesian Confidence Propagation Neural Network (BCPNN)	Bayesian-based method to prevent false-positive signals from multiple comparisons. Generate an adjusted value based on Information Component (IC)	BCPNN25: lower bound of the 2.5% of the posterior distribution for IC