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. Author manuscript; available in PMC: 2019 Dec 18.
Published in final edited form as: Biochem J. 2018 Nov 30;475(22):3669–3685. doi: 10.1042/BCJ20180637

Figure 8.

Figure 8.

The three Trk receptors undergo conformational changes in the IC region after their cognate ligands bind to their extracellular domains. Top: Schematic depiction of the changes occurring in Trk-A and Trk-B. The TM domain C-termini move apart upon ligand binding, while the distance between the C-termini of the receptors does not change in a significant way. Bottom: Schematic depiction of the changes occurring in Trk-C in response to ligand binding. The C-termini move apart upon ligand binding, but the average distance between the TM domain C-termini does not change in a significant way.