Table 2.
Dimerization parameters for the three truncated Trk receptors, in the absence of ligand and in the presence of 380 nM ligand.
| Kdiss (rec.μm−2) | ΔG (kcal/mol) | Intrinsic FRET () | d(Å) | |
|---|---|---|---|---|
| TM-Trk-A | 2271 ± 310 | −3.61 ± 0.09 | 0.96 ± 0.03 | 32 ± 5 |
| ECTM-Trk-A | 2127 ± 278 | −3.65 ± 0.08 | 0.76 ± 0.04 | 45 ± 2 |
| ECTM-Trk-A+NGF | 25 ± 5 | −6.28 ± 0.12 | 0.59 ± 0.01 | 51 ± 1 |
| ECTM-Trk-B | 2018 ± 134 | −3.68 ± 0.04 | 0.82 ± 0.02 | 42 ± 1 |
| ECTM-Trk B+BDNF | 23 ± 2 | −6.33 ± 0.06 | 0.50 ± 0.01 | 55 ± 1 |
| ECTM-Trk-C | 183 ± 29 | −5.10 ± 0.09 | 0.57 ± 0.01 | 52 ± 1 |
| ECTM-Trk-C+NT-3 | 15 ± 4 | −6.59 ± 0.16 | 0.64 ± 0.01 | 50 ± 1 |