Table 3.
Cognitive Measures
| Galantamine | Placebo | Total | Statistics: 3 Group (8, 16mg, placebo) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Task Variable (Cognitive Domain) | Timepoint | 8 mg | 16 mg | Time | Group | Groupx Time | ||||||||||
| mean | sd | n | mean | sd | n | mean | sd | n | mean | sd | n | F, p | F, p | F, p | ||
| A. Primary Cognitive Outcomes | ||||||||||||||||
| RVP A’ (Attention/Signal Detection) | Baseline (Wk 0) | 0.86 | 0.06 | 17 | 0.86 | 0.05 | 12 | 0.85 | 0.08 | 15 | 0.86 | 0.06 | 44 | .41, .53 | .38, .69 | 1.31, .28 |
| End of Treatment (Wk 12) | 0.88 | 0.07 | 17 | 0.84 | 0.12 | 12 | 0.87 | 0.08 | 15 | 0.87 | 0.09 | 44 | ||||
| Longest Digit Span Forward (Memory Capacity) | Baseline (Wk 0) | 5.9 | 1.7 | 22 | 5.7 | 1.3 | 13 | 6.4 | 2.3 | 17 | 6 | 1.8 | 52 | 17.18, .00 | 1.43, .25 | .48, .62 |
| End of Treatment (Wk 12) | 6.5 | 1.4 | 22 | 6.8 | 1 | 13 | 7.4 | 1.2 | 17 | 6.9 | 1.3 | 52 | ||||
| Longest Digit Span Backwards (Working Memory) | Baseline (Wk 0) | 4.2 | 1.7 | 22 | 3.2 | 0.9 | 13 | 4 | 1.7 | 17 | 3.9 | 1.6 | 52 | 4.9, .03 | .58, .56 | 5.89, .005 |
| End of Treatment (Wk 12) | 4.2 | 1.2 | 22 | 4.3 | 1.4 | 13 | 3.9 | 1.6 | 17 | 4.1 | 1.4 | 52 | ||||
| Stop Signal Response Time (SSRT) (Response Inhibition) | Baseline (Wk 0) | 215.3 | 89.9 | 17 | 277.2 | 142.6 | 12 | 244.1 | 111.4 | 15 | 242 | 113.5 | 44 | .01, .92 | .67, .52 | .22, .81 |
| End of Treatment (Wk 12) | 241.9 | 140.2 | 17 | 267.9 | 196.6 | 12 | 234.8 | 129.2 | 15 | 246.6 | 151.1 | 44 | ||||
| Drug Stroop Effect (Attentional Bias) | Baseline (Wk 0) | −2.25 | 13.5 | 16 | 3.1 | 5.5 | 3 | 1.5 | 4.3 | 15 | 0.6 | 9.1 | 44 | .13, .72 | .42, .66 | 2.11, .13 |
| End of Treatment (Wk 12) | 2.3 | 6.4 | 16 | 0.22 | 2.9 | 13 | 1.4 | 3.9 | 15 | 1.4 | 4.8 | 44 | ||||
| B. Secondary Cognitive Outcomes | ||||||||||||||||
| Digit Span: Forward Total Score (Memory Capacity) | Baseline (Wk 0) | 9.6 | 3 | 22 | 9.9 | 2.3 | 13 | 10.7 | 2.1 | 19 | 10.1 | 2.6 | 54 | 6.23, .02 | .78, .47 | .27, .77 |
| End of Treatment (Wk 12) | 10.5 | 2.6 | 22 | 10.7 | 1.8 | 13 | 11.2 | 3.1 | 19 | 10.8 | 2.6 | 54 | ||||
| Digit Span: Backwards Total Score (Working Memory) | Baseline (Wk 0) | 8.3 | 3.1 | 22 | 7.2 | 1.5 | 13 | 7.6 | 1.9 | 19 | 7.8 | 2.4 | 54 | .79, .38 | .82, .44 | 2.03, .14 |
| End of Treatment (Wk 12) | 8.3 | 2.1 | 22 | 8.5 | 2.7 | 13 | 7.3 | 2.7 | 19 | 8 | 2.5 | 54 | ||||
| RVP: B” (Response Bias) | Baseline (Wk 0) | 0.77 | 0.42 | 17 | 0.91 | 0.13 | 12 | 0.77 | 0.22 | 15 | 0.81 | 0.3 | 44 | 2.13, .15 | .20, .82 | 4.44, .02 |
| End of Treatment (Wk 12) | 0.81 | 0.16 | 17 | 0.57 | 0.56 | 12 | 0.81 | 0.19 | 15 | 0.74 | 0.34 | 44 | ||||
| RVP: False Alarm (Motor Impulsivity) | Baseline (Wk 0) | 0.04 | 0.08 | 17 | 0.01 | 0.02 | 12 | 0.03 | 0.04 | 15 | 0.03 | 0.05 | 44 | .03, .87 | .18, .84 | 1.93, .16 |
| End of Treatment (Wk 12) | 0.03 | 0.03 | 17 | 0.03 | 0.04 | 12 | 0.02 | 0.02 | 15 | 0.03 | 0.03 | 44 | ||||
| SST: Median Correct Go RT (Response Speed) | Baseline (Wk 0) | 706.3 | 260 | 17 | 619.7 | 285.7 | 12 | 680 | 158.3 | 15 | 673.7 | 235.4 | 44 | .87, .36 | .02, .99 | 1.51, .23 |
| End of Treatment (Wk 12) | 608.6 | 201.6 | 17 | 669.7 | 323.5 | 12 | 631.5 | 150.6 | 15 | 633.1 | 223.3 | 44 | ||||
| SST: SD Correct Go RT (Attention) | Baseline (Wk 0) | 276.5 | 138.5 | 17 | 302.3 | 174.6 | 12 | 363.4 | 214.4 | 15 | 313.1 | 177 | 44 | 3.36, .07 | 1.05, .36 | .15, .86 |
| End of Treatment (Wk 12) | 337.8 | 262.9 | 17 | 410.6 | 276.1 | 12 | 492.6 | 530.5 | 15 | 410.4 | 375.9 | 44 | ||||
| Drug Stroop: Mean RT for Correct Neutral Trials | Baseline (Wk 0) | 791.8 | 189.4 | 16 | 808.2 | 112.7 | 13 | 854.5 | 142.2 | 15 | 818 | 153 | 44 | 4.64, .04 | .78, .47 | .52, .60 |
| End of Treatment (Wk 12) | 772.0 | 186 | 16 | 750 | 138.2 | 13 | 828.7 | 180.1 | 15 | 784.8 | 170.5 | 44 | ||||
| Drug Stroop: Mean RT for Correct Drug Trials | Baseline (Wk 0) | 789.5 | 191 | 16 | 811.2 | 112.6 | 13 | 856 | 140.8 | 15 | 818.6 | 153.4 | 44 | 4.48, .04 | .79, .46 | .71, .50 |
| End of Treatment (Wk 12) | 774.3 | 184.8 | 16 | 750.3 | 139.1 | 13 | 830.1 | 179.9 | 15 | 786.2 | 170.2 | 44 | ||||
Abbreviations: RVP= Rapid Visual Information Processing Task; SST= Stop Signal Task; RT= Response Time; Wk= Week Bold indicates statistical significance (p<0.05); bold italics indicate a trend significance (p<0.10).