Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 9;146(23):dev185314. doi: 10.1242/dev.185314

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019. Published by The Company of Biologists Ltd

PMC Copyright notice

Fig. 6. — Effect of Rubie ablation on heart development at E15.5. (A-C,E) Oblique transverse Hematoxylin and Eosin histological sections of cardiac ventricular and OFT morphogenesis at E15.5. (A) Representative wild-type morphology. (B) Representative Rubie^−/− morphology. (C) Representative Bmp4^+/− (Actb-Cre⁺) morphology. (D) Left: electrophoresed gDNA PCR genotyping products of Rubie and Actb-Cre transgene alleles. Right: offspring recovered at weaning from Rubie^+/−; Actb-Cre⁺×Bmp4^fl/fl mating versus expected Mendelian ratios. (E) Representative Bmp4^+/−; Rubie^+/− (Actb-Cre⁺) morphology in two separate individuals. RV, right ventricle; LV, left ventricle; OFT, outflow tract; WT, wild type. Scale bars: 300 µm. Arrows indicate distorted OFT orientation. P-values were obtained using a χ² test.