Fig. 5.

Notch4 IC deletion rescues cortical tubulointerstitial and glomerular injury. (A,C) Kidney paraffin sections from Tg26⁺ and Notch4-deleted Tg26 (N4d1/Tg26⁺) mice (n=5 each) were subjected to periodic acid–Schiff staining and blindly evaluated for glomerular and tubulointerstitial injury. The arrowhead indicates sclerotic glomeruli. Note the hypercellularity in the Tg26⁺ mice sections. (B,D) Percentage glomerular or tubulointerstitial injury was measured per kidney (n=5) for each group of mice. Statistical values were obtained using unpaired Student's t-test (*P<0.05, **P<0.01).