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. 2019 Dec 9;8(12):bio046474. doi: 10.1242/bio.046474

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Gene expression in OFT is deregulated in tnnt2a mutant zebrafish with myocardial tnnt2a supplementation. (A) Workflow of sample collections for whole-fish RNA-seq of four groups: tnnt2^+/−, tnnt2a^−/− Tg(myl7:tnnt2a); tnnt2a^−/− and Tg(myl7:tnnt2a); tnnt2a^+/−. (B) Volcano plot of differentially expressed genes in tnnt2a^+/− versus Tg(myl7:tnnt2a); tnnt2a^−/−. (C,D) Sarcomere- and OFT-relevant gene expression in dissected heart of tnnt2a^+/+, tnnt2a^−/−, and Tg(myl7:tnnt2a); tnnt2a^−/− after DOX induction at 16 hpf. *P<0.05, ***P<0.001, ****P<0.0001, NS, not significant; n=30 per group. Statistical differences were evaluated using two-way ANOVA. Red asterisks, sarcomere genes in Tg(myl7:tnnt2a); tnnt2a^−/− can almost return to wild-type level after DOX induction; red hashes, OFT-relevant genes in Tg(myl7:tnnt2a); tnnt2a^−/− are more deviated from wild-type level after DOX induction compared with tnnt2a^−/−.