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. 2019 Dec 4;146(23):dev178855. doi: 10.1242/dev.178855

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© 2019. Published by The Company of Biologists Ltd

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Fig. 1. — Yap deletion examined at different developmental stages of the mouse esophagus. (A,B) Yap expression is incompletely ablated in the esophageal epithelium of Shh-Cre;Yap^loxp/loxp (Yap KO) mutants at E10.5 and E11.5 (n=3). Note the complete loss of Yap in the ventral esophageal epithelium (arrows). (C,D) Yap expression is completely ablated in the esophageal epithelium of Shh-Cre;Yap^loxp/loxp (Yap KO) mutants at E12.5 and E18.5. Note that expression of YAP is nuclear in EPCs at E10.5, and nuclear expression of Yap is localized to basally located EPCs at E11.5, E12.5 and E15.5. Apically oriented cells express cytoplasmic Yap starting at E11.5, E12.5 and E18.5. Note expression of both cytoplasmic and nuclear staining of YAP in wild type at E12.5 (arrows) and mostly nuclear in the basal cells (arrows) at E18.5 (n=3). Dotted line encircles the epithelium. d, dorsal; Epi, epithelium; es, esophagus; tr, trachea; v, ventral. Scale bars: 20 µm.