Figure 1.

Upregulation of SYK expression in peritoneal fibrosis. (A) Photomicrograph of the histology of changes in peritoneal tissue in the rat model of peritoneal fibrosis compared with the control. There is mesothelial cell hyperplasia and peritoneal thickening in the chlorhexidine digluconate-induced peritoneal fibrosis model group compared with the normal control group. Scale bar, 500 μm. (B) Immunohistochemistry and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) were used to detect the expression of SYK. Scale bar, 500 μm. ** P<0.01 vs. sham. (C) The expression of inflammatory cytokines, IL-1β, TNF-α, IL-6, and MCP-1 in rat serum were detected. ** P<0.01 and *** P<0.001 vs. sham. (D) The expression of SYK was significantly correlated with the levels of various inflammatory cytokines. All experiments were independently conducted in triplicate. CG – chlorhexidine digluconate.