Table 1:
Disease and transplant characteristics of evaluated patients
| (N=101) | |
|---|---|
| Age at transplant | |
| Median, Range | 59 (30.0–73.4) |
| < 50 | 13 (12.9%) |
| 50 – 65 | 75 (74.3%) |
| > 65 | 13 (12.9%) |
| Gender: Male | 60 (59.4%) |
| Diagnosis | |
| PMF | 62 (61.4%) |
| Post ET MF | 20 (19.8%) |
| Post PV MF | 18 (17.8%) |
| MPN-U | 1 (1.0%) |
| DIPSS | |
| Low Risk | 9 (8.9%) |
| Int-1 | 36 (35.6%) |
| Int-2 | 41 (40.6%) |
| High Risk | 15 (14.9%) |
| MIPSS-70 | |
| Missing | 21 |
| High Risk | 48 (60.0%) |
| Intermediate Risk | 29 (36.3%) |
| Low Risk | 3 (3.8%) |
| Cytogenetics | |
| Missing | 15 |
| Favorable | 61 (70.9%) |
| Unfavorable | 25 (29.1%) |
| 3 or more somatic mutations | |
| Yes | 30 (29.7%) |
|
HMR: Presence of one of the mutations ASXL1/SRSF2/IDH1/2/EZH2/T P53 |
|
| Yes | 37 (36.6%) |
| MPN Triple Negative (no for JAK2,MPL and CALR) | |
| Yes | 22 (21.8%) |
| Spleen status | |
| Splenectomy | 11 (10.9%) |
| Splenomegaly | 69 (68.3%) |
| No splenomegaly | 21 (20.8%) |
| Time from Diagnosis to Transplant (years) | |
| Median, range | 1.9 (0.1–28.4) |
| Donor | |
| MRD | 46 (45.5%) |
| MUD | 52 (51.5%) |
| Mismatch | 3 (3.0%) |
| Donor age | |
| Missing | 17 |
| Median, Range | 45.5 (18.0–73.0) |
| Conditioning Regimen | |
| MAC | 18 (17.8%) |
| RIC | 83 (82.2%) |