Table 2.

Analysis of risk factors associated with wound healing and major amputation over 1 year

Characteristics	Wound Healing				Major Amputation
	Univariate Analysis		Multivariable Model		Univariate Analysis		Multivariable Model
	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Baseline hemoglobin A1c	1.16 (0.87–1.55)	0.32			0.72 (0.49–1.06)	0.10
Nadir hemoglobin A1c	0.95 (0.73–1.23)	0.70			0.94 (0.67–1.31)	0.72
Peripheral arterial disease	0.16 (0.04–0.67)	0.01	0.43 (0.09–2.11)	0.30	0.97 (0.04–0.92)	0.99
Wound area	0.98 (0.93–1.03)	0.33			0.99 (0.93–1.06)	0.78
Wound depth	1.91 (1.05–3.51)	0.04	1.77 (0.88–3.57)	0.11	0.46 (0.20–1.03)	0.06
Infection	0.07 (0.04–0.12)	0.89			0.98 (0.02–0.94)	0.99
Time from onset to assessment	1.19 (0.98–1.45)	0.08			0.84 (0.65–1.08)	0.17
Direct angiosome perfusion	4.34 (2.12–8.89)	<0.01	1.03 (0.38–2.8)	0.95	0.11 (0.04–0.31)	<0.01	1.36 (0.32–5.77)	0.68
DUSS	0.23 (0.14–0.39)	<0.01	2.53 (0.35–4.35)	0.21	2.65 (6.59–8.82)	<0.01	0.75 (0.10–5.08)	0.14
WIfI score	0.33 (0.20–0.55)	<0.01	2.03 (0.85–4.85)	0.11	9.70 (2.46–38.3)	0.01	1.81 (0.29–11.2)	0.52
citH3	0.07 (0.04–0.12)	<0.01	0.07 (0–1.27)	0.003	0.99 (0.83–4.94)	<0.01	0.89 (0.50–10.6)	0.02
cfDNA	0.99 (0.99–1.00)	<0.01	0.22 (0–4.61)	0.73	1.00 (0.98–1.01)	0.05	1.00 (0.99–1.02)	0.89
Nucleosomes	0.02 (0.01–0.09)	<0.01	0.38 (0.01–10.4)	0.57	3.71 (1.09–12.7)	0.04	0.64 (0.02–18.7)	0.79
Elastase	0.01 (0–0.03)	<0.01	0.20 (0.07–0.57)	0.07	4.41 (0.5–38.7)	0.18

cfDNA, cell-free DNA; citH3, citrullinated histone 3.