Table 1.
Tumor Doubling Rates in Patients Who Underwent Pre- and Post-Point of Enlargement Active Surveillance
| No. of patients | Tumor doubling rate (per year) |
||||
|---|---|---|---|---|---|
| >0.5, n (%) | 0.1–0.5, n (%) | −0.1 to 0.1, n (%) | <−0.1, n (%) | ||
| Pre-PE-M | 69 | 35 (50.8) | 32 (46.4) | 1 (1.4) | 1 (1.4) |
| Post-PE-M | 78 | 6 (7.7) | 10 (12.8) | 25 (32.1) | 37 (47.4) |
| Pre-PE-V | 197 | 77 (39.1) | 99 (50.2) | 20 (10.2) | 1 (0.5) |
| Post-PE-V | 291 | 11 (3.8) | 35 (12.1) | 140 (48.1) | 105 (36.1) |
PE, point of enlargement; PE-M, time at which maximal tumor size increased by ≥3 mm; PE-V, time at which tumor volume increased by ≥50%. Results of statistical analysis for pre-PE-M versus post-PE-M: p < 0.001, and pre-PE-V versus post PE-V: p < 0.001.