Table 2.
Metabolite | SHIP-TREND (n = 856) |
Thyrotoxicosis study (N = 16 × 5 time points) |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Spearman's correlation 3,5-T2 |
3,5-T2 groups (ref.: <0.20 nM) |
log(3,5-T2) (>0.20 nM) |
log(3,5-T2) (>0.20 nM) |
|||||||||||
0.20–0.33 nM |
>0.33 nM |
|||||||||||||
N | Rho | p | N | βa[95% CI] | FDR | N | βa[95% CI] | FDR | N | βa[95% CI] | FDR | βb[95% CI] | FDR | |
Caffeine | 836 | 0.41 | 2.73E-35 | 257 | 0.42 [0.27–0.57] | 5.44E-05 | 267 | 1.01 [0.86–1.16] | 1.24E-33 | 538 | 0.38 [0.23–0.53] | 4.23E-04 | 0.63 [0.41–0.85] | 4.61E-03 |
Paraxanthine | 830 | 0.39 | 1.80E-31 | 257 | 0.39 [0.23–0.54] | 4.62E-04 | 268 | 0.85 [0.7–1.01] | 1.14E-23 | 539 | 0.34 [0.19–0.5] | 1.34E-03 | 0.57 [0.4–0.74] | 1.63E-03 |
Theobromine | 833 | 0.12 | 4.81E-04 | 255 | 0.11 [−0.06 to 0.27] | 8.34E-01 | 268 | 0.33 [0.17–0.49] | 4.98E-03 | 537 | 0.03 [−0.13 to 0.19] | 9.69E-01 | 0.28 [0.1–0.47] | 1.24E-01 |
Theophylline | 754 | 0.38 | 6.54E-27 | 243 | 0.34 [0.17–0.5] | 1.31E-02 | 250 | 0.92 [0.75–1.08] | 6.84E-24 | 505 | 0.43 [0.27–0.59] | 1.49E-04 | 0.5 [0.38–0.62] | 4.94E-04 |
1,7-Dimethylurate | 616 | 0.32 | 8.88E-16 | 194 | 0.38 [0.19–0.57] | 1.31E-02 | 226 | 0.81 [0.63–0.99] | 3.34E-15 | 428 | 0.3 [0.12–0.48] | 7.32E-02 | 0.51 [0.38–0.64] | 4.94E-04 |
3-(4-Hydroxyphenyl)lactate | 791 | 0.11 | 1.31E-03 | 241 | 0.18 [0.03–0.33] | 5.46E-01 | 259 | 0.27 [0.13–0.42] | 1.02E-02 | 512 | 0.05 [−0.08 to 0.19] | 9.20E-01 | 0.04 [0.01–0.08] | 2.19E-01 |
Trigonelline | 785 | 0.29 | 3.36E-16 | 241 | 0.25 [0.08–0.41] | 3.01E-01 | 257 | 0.69 [0.53–0.85] | 3.31E-14 | 510 | 0.39 [0.23–0.56] | 1.10E-03 | −0.03 [−0.15 to 0.08] | 7.76E-01 |
Cyclo(leu-pro) | 794 | 0.27 | 1.20E-14 | 241 | 0.33 [0.16–0.49] | 1.31E-02 | 263 | 0.67 [0.51–0.83] | 5.24E-14 | 517 | 0.31 [0.15–0.46] | 1.04E-02 | 0.07 [−0.03 to 0.16] | 4.88E-01 |
3-Methyl catechol sulfate (1) | 523 | 0.19 | 7.50E-06 | 160 | 0.07 [−0.14 to 0.28] | 9.13E-01 | 180 | 0.47 [0.27–0.67] | 3.89E-04 | 346 | 0.38 [0.17–0.59] | 2.90E-02 | 0.21 [−0.01 to 0.44] | 3.29E-01 |
Catechol sulfate | 832 | 0.14 | 3.69E-05 | 255 | 0.14 [−0.02 to 0.3] | 7.48E-01 | 266 | 0.35 [0.19–0.51] | 1.00E-03 | 535 | 0.13 [−0.02 to 0.29] | 6.59E-01 | 0.05 [−0.03 to 0.13] | 5.15E-01 |
Linear regression models adjusted for age, sex, waist circumference, blood sampling time, as well as serum concentrations of fT4 and thyrotropin, %-change compared with the lowest group could be achieved by exponentiation of the beta-estimate to the base of 2 and subtraction of 1 multiplied by 100 [(2β−1)×100].
Mixed effects linear regression model adjusted for age, body mass index, and fT4 concentrations.
CI, confidence interval; FDR, false discovery rate; ref., reference group; SHIP-TREND, Study of Health in Pomerania-TREND.