Skip to main content
. 2019 Dec 16;29(12):1743–1754. doi: 10.1089/thy.2018.0549

Table 2.

Estimates for Significantly Associated Metabolites That Are Also Available in the Thyrotoxicosis Sample

Metabolite SHIP-TREND (n = 856)
Thyrotoxicosis study (N = 16 × 5 time points)
Spearman's correlation 3,5-T2
3,5-T2 groups (ref.: <0.20 nM)
log(3,5-T2) (>0.20 nM)
log(3,5-T2) (>0.20 nM)
0.20–0.33 nM
>0.33 nM
N Rho p N βa[95% CI] FDR N βa[95% CI] FDR N βa[95% CI] FDR βb[95% CI] FDR
Caffeine 836 0.41 2.73E-35 257 0.42 [0.27–0.57] 5.44E-05 267 1.01 [0.86–1.16] 1.24E-33 538 0.38 [0.23–0.53] 4.23E-04 0.63 [0.41–0.85] 4.61E-03
Paraxanthine 830 0.39 1.80E-31 257 0.39 [0.23–0.54] 4.62E-04 268 0.85 [0.7–1.01] 1.14E-23 539 0.34 [0.19–0.5] 1.34E-03 0.57 [0.4–0.74] 1.63E-03
Theobromine 833 0.12 4.81E-04 255 0.11 [−0.06 to 0.27] 8.34E-01 268 0.33 [0.17–0.49] 4.98E-03 537 0.03 [−0.13 to 0.19] 9.69E-01 0.28 [0.1–0.47] 1.24E-01
Theophylline 754 0.38 6.54E-27 243 0.34 [0.17–0.5] 1.31E-02 250 0.92 [0.75–1.08] 6.84E-24 505 0.43 [0.27–0.59] 1.49E-04 0.5 [0.38–0.62] 4.94E-04
1,7-Dimethylurate 616 0.32 8.88E-16 194 0.38 [0.19–0.57] 1.31E-02 226 0.81 [0.63–0.99] 3.34E-15 428 0.3 [0.12–0.48] 7.32E-02 0.51 [0.38–0.64] 4.94E-04
3-(4-Hydroxyphenyl)lactate 791 0.11 1.31E-03 241 0.18 [0.03–0.33] 5.46E-01 259 0.27 [0.13–0.42] 1.02E-02 512 0.05 [−0.08 to 0.19] 9.20E-01 0.04 [0.01–0.08] 2.19E-01
Trigonelline 785 0.29 3.36E-16 241 0.25 [0.08–0.41] 3.01E-01 257 0.69 [0.53–0.85] 3.31E-14 510 0.39 [0.23–0.56] 1.10E-03 −0.03 [−0.15 to 0.08] 7.76E-01
Cyclo(leu-pro) 794 0.27 1.20E-14 241 0.33 [0.16–0.49] 1.31E-02 263 0.67 [0.51–0.83] 5.24E-14 517 0.31 [0.15–0.46] 1.04E-02 0.07 [−0.03 to 0.16] 4.88E-01
3-Methyl catechol sulfate (1) 523 0.19 7.50E-06 160 0.07 [−0.14 to 0.28] 9.13E-01 180 0.47 [0.27–0.67] 3.89E-04 346 0.38 [0.17–0.59] 2.90E-02 0.21 [−0.01 to 0.44] 3.29E-01
Catechol sulfate 832 0.14 3.69E-05 255 0.14 [−0.02 to 0.3] 7.48E-01 266 0.35 [0.19–0.51] 1.00E-03 535 0.13 [−0.02 to 0.29] 6.59E-01 0.05 [−0.03 to 0.13] 5.15E-01
a

Linear regression models adjusted for age, sex, waist circumference, blood sampling time, as well as serum concentrations of fT4 and thyrotropin, %-change compared with the lowest group could be achieved by exponentiation of the beta-estimate to the base of 2 and subtraction of 1 multiplied by 100 [(2β−1)×100].

b

Mixed effects linear regression model adjusted for age, body mass index, and fT4 concentrations.

CI, confidence interval; FDR, false discovery rate; ref., reference group; SHIP-TREND, Study of Health in Pomerania-TREND.