Table 3. Stratified analysis for associations between surgery of primary sites and OS of stage IVB cervical cancer patients receiving CRT (matched).
| Select covariates | Treatment | |||||
|---|---|---|---|---|---|---|
| Total/death | HR | 95% CI | p | |||
| Age at diagnosis | ||||||
| ≤50 | 132/68 | 0.32 | 0.15–0.68 | 0.003 | ||
| >50 | 84/42 | 0.17 | 0.06–0.50 | 0.001 | ||
| Race | ||||||
| White | 170/81 | 0.34 | 0.18–0.65 | <0.001 | ||
| Black | 27/18 | <0.01 | 4.01–448,500 | 0.015 | ||
| Other* | 19/3 | - | - | 0.999 | ||
| Marital status | ||||||
| No | 94/42 | 0.50 | 0.15–1.61 | 0.243 | ||
| Yes | 107/57 | 0.20 | 0.08–0.47 | <0.001 | ||
| Insurance record | ||||||
| No | 21/12 | - | - | 0.998 | ||
| Yes | 192/96 | 0.36 | 0.20–0.63 | <0.001 | ||
| Grade | ||||||
| I–II | 92/44 | 0.12 | 0.03–0.41 | <0.001 | ||
| III–IV | 97/55 | 0.47 | 0.22–1.02 | 0.056 | ||
| Histology | ||||||
| SCC | 123/57 | 0.67 | 0.30–1.55 | 0.366 | ||
| Adenocarcinoma | 50/28 | 0.18 | 0.04–0.88 | 0.034 | ||
| Other† | 43/25 | <0.01 | 0.00–0.02 | <0.001 | ||
| Tumor size (cm) | ||||||
| ≤4 | 152/72 | 0.22 | 0.11–0.46 | <0.001 | ||
| >4 | 41/20 | 0.89 | 0.18–4.41 | 0.888 | ||
| AJCC T stage | ||||||
| T1 | 78/30 | - | - | 0.997 | ||
| T2 | 68/35 | 0.60 | 0.24–1.52 | 0.286 | ||
| T3 | 60/39 | 0.26 | 0.09–0.81 | 0.021 | ||
| T4 | 10/6 | - | - | - | ||
| AJCC N stage | ||||||
| N0 | 54/26 | 0.43 | 0.09–2.22 | 0.327 | ||
| N1 | 156/80 | 0.30 | 0.16–0.56 | <0.001 | ||
| Visceral metastasis | ||||||
| No | 122/53 | 0.31 | 0.14–0.70 | 0.005 | ||
| Yes | ||||||
| Distant organ only | 52/30 | 1.38 | 0.28–6.70 | 0.590 | ||
| Distant LN plus organ | 35/22 | 0.03 | 0.00–0.34 | 0.005 | ||
The results were adjusted for age at diagnosis, race, marital status, insurance record, grade, histology, AJCC T stage, AJCC N stage, visceral metastasis, and the significant results in bold, if p<0.05.
AJCC, American Joint Committee on Cancer; CI, confidence interval; CRT, chemoradiotherapy; HR, hazards ratio; LN, lymph node; NOS, not otherwise specified; OS, overall survival; SCC, squamous cell carcinoma.
*Race–others (Asian or Pacific Islander; American Indian/Alaska Native); †Histology–others (epithelial neoplasms, NOS; transitional cell papillomas and carcinomas; cystic, mucinous and serous neoplasms; complex epithelial neoplasms; complex mixed and stromal neoplasms; unspecified neoplasms).