Fig.1.

Transplantation of MSC improved spatial memory function of APdE9 mice. a) Schematic diagram of the protocol. To assess spatial learning and memory function, Morris water maze test was performed in WT, APdE9-sham, and APdE9-MSC mice at 8.5 months of age. EPR imaging was performed at 9 months of age. b) Escape latency in the training trials of Morris water maze test for WT mice, APdE9-sham mice, and APdE9-MSC mice. c) Swimming speed in the probe trial of Morris water maze test for three groups of mice. d) Number of crossing through the area where the platform was located, e) latency to reach where the platform was located, and f) percentage of time spent in target quadrant in the probe trial of Morris water maze test (n = 10 for each group).