Table 1.

Rank order of discriminating biochemical pathways

No.	Pathway Name	Measured Metabolites in the Pathway (N)	Expected Pathway Proportion (P = N/383)	Expected Hits in Sample of 52 (P * 52)	Observed Hits in the Top 52 Metabolites	Fold Enrichment (Obs/Exp)	Impact (Sum VIP Scores)	Fraction of Impact Explained (% of 96.8)	Increased	Decreased
1	Phospholipid Metabolism	75	0.196	10.2	13	1.3	25.63	26%	12	1
2	Glycosphingolipid Metabolism	10	0.026	1.4	4	2.9	7.44	8%	2	2
3	Purine Metabolism	24	0.063	3.3	4	1.2	6.48	7%	4	0
4	SAM, SAH, Methionine, Cysteine, Glutathione	13	0.034	1.8	3	1.7	6.01	6%	3	0
5	Sphingomyelin Metabolism	36	0.094	4.9	3	0.6	5.78	6%	3	0
6	GABA, Glutamate, Arginine, Ornithine, Proline	5	0.013	0.7	3	4.4	5.07	5%	3	0
7	Tryptophan, Kynurenine, Serotonin, Melatonin	5	0.013	0.7	2	2.9	4.50	5%	2	0
8	Krebs Cycle	13	0.034	1.8	2	1.1	4.05	4%	2	0
9	Histidine, Histamine, Carnosine Metabolism	4	0.010	0.5	2	3.7	3.56	4%	2	0
10	Lysine Metabolism	3	0.008	0.4	2	4.9	3.48	4%	2	0
11	Nitric Oxide, Superoxide, Peroxide Metabolism	2	0.005	0.3	2	7.4	3.29	3%	1	1
12	1-Carbon, Folate Metabolism	6	0.016	0.8	1	1.2	2.59	3%	1	0
13	Amino-Sugar, Galactose, &Non-Glucose	6	0.016	0.8	1	1.2	2.25	2%	1	0
14	Plasmalogen Metabolism	7	0.018	1.0	1	1.1	1.83	2%	0	1
15	Pyrimidine Metabolism	14	0.037	1.9	1	0.5	1.81	2%	1	0
16	Vitamin B1 (Thiamine) Metabolism	2	0.005	0.3	1	3.7	1.70	2%	1	0
17	Cardiolipin Metabolism	8	0.021	1.1	1	0.9	1.67	2%	1	0
18	Vitamin C (Ascorbate) Metabolism	2	0.005	0.3	1	3.7	1.65	2%	1	0
19	Fatty Acid Oxidation and Synthesis	39	0.102	5.3	1	0.2	1.64	2%	0	1
20	Bioamines and Neurotransmitter Metabolism	7	0.018	1.0	1	1.1	1.62	2%	1	0
21	Glycolysis and Gluconeogenesis Metabolism	11	0.029	1.5	1	0.7	1.61	2%	1	0
22	Microbiome Metabolism	12	0.031	1.6	1	0.6	1.60	2%	1	0
23	Urea Cycle	2	0.005	0.3	1	3.7	1.54	2%	1	0
								Subtotal	46	6
								Total	52