TABLE 3. Oral antimicrobial dosages for use in adults in conjunction with anthrax vaccine adsorbed for postexposure prophylaxis.
Strain | Drug and dosage* |
---|---|
For all strains, regardless of penicillin susceptibility or if susceptibility is unknown |
Ciprofloxacin,† 500 mg every 12 hrs |
Doxycycline,† 100 mg every 12 hrs | |
Levofloxacin, 750 mg every 24 hrs | |
Moxifloxacin,§ 400 mg every 24 hrs | |
Clindamycin,§ 600 mg every 8 hrs | |
Alternatives for penicillin-susceptible strains | Amoxicillin,§ 1,000 mg every 8 hrs |
Penicillin VK,§ 500 mg every 6 hrs |
Abbreviations: FDA = Food and Drug Administration; PEP-Abx = antimicrobial postexposure prophylaxis.
* Any one of these drug regimens.
† First-line drugs; alternative drugs are listed in order of preference for PEP-Abx for patients who cannot take first-line treatment or if first-line PEP-Abx is unavailable.
§ Not FDA approved for PEP-Abx of inhalation anthrax.