Table 4.
Binary logistic regression analysis of poor-prognosis-matched cohort with or without GH
| Variable | Clinical pregnancy likelihood in the age-matched cohort |
Live birth likelihood in the age-matched cohort |
||
|---|---|---|---|---|
| Odds ratio (95% CI) | p-value | Odds ratio (95% CI) | p-value | |
| Univariate regression | ||||
| Treatment type | ||||
| (–)GH | 1 | - | 1 | - |
| (+)GH | 1.40 (0.72–2.69) | 0.319 | 1.84 (0.88–3.81) | 0.103 |
| Cycle age | 0.87 (0.81–0.94) | 0.001 | 0.86 (0.79–0.93) | < 0.005 |
| Embryo age | 0.88 (0.82–0.95) | 0.001 | 0.86 (0.79–0.94) | < 0.005 |
| Serum AMH | 1.02 (0.98–1.06) | 0.286 | 1.03 (0.99–1.06) | 0.155 |
| BMI | 0.99 (0.93–1.05) | 0.75 | 1.00 (0.94–1.07) | 0.913 |
| Midluteal progesterone | 1.01 (1.00–1.02) | 0.212 | 1.00 (0.99–1.01) | 0.665 |
| AFC group | ||||
| A (≥ 20 follicles) | 1 | - | 1 | - |
| B/C (9–19 follicles) | 0.40 (0.15–1.07) | 0.069 | 0.42 (0.16–1.16) | 0.096 |
| D/E (≤ 8 follicles) | 0.27 (0.10–0.67) | 0.005 | 0.21 (0.08–0.57) | 0.002 |
| Quality of transferred embryo | ||||
| High-quality blastocyst (day 5) | 1 | - | 1 | - |
| Medium/low-quality blastocyst (day 5) | 0.62 (0.30–1.28) | 0.198 | 0.56 (0.25–1.22) | 0.142 |
| High-quality day 3 | 0.13 (0.04–0.49) | 0.002 | 0.13 (0.03–0.58) | 0.008 |
| Low-quality day 3 | NC | NC | NC | NC |
| Multivariate regressiona) | ||||
| Treatment type | ||||
| (–)GH | 1 | - | 1 | - |
| (+)GH | 1.77 (0.83–3.77)a) | 0.14 | 2.71 (1.14 – 6.46)a) | 0.024 |
GH, growth hormone; CI, confidence interval; AMH, anti-Müllerian hormone; BMI, body mass index; AFC, antral follicle count; NC, not computed as the case number was too low.
a)
Adjusted for embryo age, serum AMH level, AFC, and transferred embryo quality with embryo age and transferred embryo quality remaining independently significant.