Table 3.

Multivariable analysis¹ of survival predictors for Burkitt’s Lymphoma in children, adults and elderly in current study

	Children		Adults		Elderly
	HR (95% CI)	p values	HR (95% CI)	p values	HR (95% CI)	p values
Race
White	Ref.		Ref.		Ref.
Black	1.57 (0.75–3.30)	0.23	1.49 (1.23–1.81)	<0.0001	1.02 (0.69–1.50)	0.92
Asian or Pacific Islander	0.97 (0.38–2.46)	0.95	1.02 (0.80–1.30)	0.87	0.80 (0.59–1.08)	0.14
Others	–		1.19 (0.60–2.39)	0.63	1.27 (0.47–3.43)	0.63
Primary site
Lymph node	Ref.		Ref.		Ref.
Head & neck	0.89 (0.20–3.84)	0.87	0.66 (0.37–1.17)	0.15	1.35 (0.84–2.15)	0.22
GI tract	0.65 (0.22–1.89)	0.43	0.98 (0.80–1.19)	0.82	0.94 (0.74–1.21)	0.63
Bone marrow	1.89 (0.41–8.76)	0.42	1.35 (0.99–1.86)	0.06	1.12 (0.77–1.61)	0.56
CNS	–		1.07 (0.66–1.75)	0.16	1.15 (0.54–2.44)	0.72
Others	0.50 (0.17–1.46)	0.21	0.94 (0.74–1.20)	0.65	0.86 (0.63–1.17)	0.33
Number of primaries
1	Ref.		Ref.		Ref.
2	4.11 (1.57–10.76)	0.004	1.29 (1.11–1.49)	0.001	1.10 (0.91–1.32)	0.32
>3	–		2.43 (1.59–3.72)	<0.0001	1.65 (1.18–2.29)	0.003
Year of diagnosis
2000–2004	Ref.		Ref.		Ref.
2005–2009	0.75 (0.42–1.33)	0.32	0.85 (0.73–0.98)	0.03	1.10 (0.91–1.34)	0.32
2010–2013	0.59 (0.29–1.21)	0.15	0.80 (0.68–0.94)	0.01	1.10 (0.89–1.38)	0.38
Stage
I	Ref.		Ref.		Ref.
II	1.44 (0.38–5.43)	0.59	1.11 (0.85–1.47)	0.45	1.53 (1.13–2.09)	0.01
III	2.77 (0.80–9.63)	0.11	1.67 (1.26–2.23)	0.0004	1.45 (1.02–2.06)	0.04
IV	5.15 (1.78–14.92)	0.003	2.32 (1.88–2.87)	<0.0001	1.90 (1.45–2.46)	<0.0001
Unknown	2.42 (0.41–14.16)	0.33	1.99 (1.40–2.81)	0.0001	1.76 (1.22–2.54)	0.002

¹Model adjusted for sex.

Abbreviation: CI: confidence interval; HR: hazard ratio; Ref: reference.

Bold: Statistically significant at the 0.05 level.