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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Proteome Res. 2019 Jan 3;18(2):585–593. doi: 10.1021/acs.jproteome.8b00802

Figure 3: Average target-decoy competition.

Figure 3:

The procedure is similar to TDC (Figure 1), except that each target competes against multiple decoys and losses are counted fractionally. A target is eliminated only when the rounded fractional count of losses reaches the next integer value. As in TDC+, FDR for aTDC+ is estimated via Equation 1. Note that decoys for lower-ranking targets that receive high scores (e.g., decoy 2 in line 277) can contribute to the cumulative decoy count for lines above them in the list.