Table 2.
Comparison of SCD stakeholders with genetics professionals
| Patients/parents, N = 75 | Genetics professionals, N = 472 | χ2, p-value | |
|---|---|---|---|
| Parents and guardians have a right to edit genes of their children before they are born | |||
| Agree strongly/agree | 33 (44.0%) | 207 (43.9%) | 0.036, p = 0.98 |
| Neutral | 19 (25.3%) | 124 (26.3%) | |
| Disagree strongly/disagree | 23 (30.7%) | 141 (29.9%) | |
| Missing | 0 (0%) | 0 (0%) | |
| Germline human gene editing is acceptable if alternative treatments are more expensive | |||
| Agree strongly/agree | 29 (38.7%) | 180 (38.1%) | 2.48, p = 0.48 |
| Neutral | 23 (30.7%) | 115 (24.4%) | |
| Disagree strongly/disagree | 22 (29.3%) | 174 (36.9%) | |
| Missing | 1 (1.3%) | 3 (0.6%) | |
| Germline human gene editing is acceptable if there are no alternative treatments available | |||
| Agree strongly/agree | 38 (50.7%) | 286 (60.6%) | 3.20, p = 0.36 |
| Neutral | 20 (26.7%) | 99 (21.0%) | |
| Disagree strongly/disagree | 15 (20.0%) | 81 (17.2%) | |
| Missing | 2 (2.7%) | 6 (1.3%) | |
| Germline human gene editing goes against my cultural beliefs | |||
| Agree strongly/agree | 19 (25.3%) | 65 (13.8%) | 12.44, p = 0.006 |
| Neutral | 20 (26.7%) | 82 (17.4%) | |
| Disagree strongly/disagree | 36 (48.0%) | 320 (67.8%) | |
| Missing | 0 (0%) | 5 (1.1%) | |
| Germline human gene editing goes against my religious beliefs | |||
| Agree strongly/agree | 16 (21.3%) | 52 (11.0%) | 12.83, p = 0.005 |
| Neutral | 18 (24.0%) | 69 (14.6%) | |
| Disagree strongly/disagree | 40 (53.3%) | 345 (73.1%) | |
| Missing | 1 (1.3%) | 4 (0.9%) | |
| Germline human gene editing is morally acceptable | |||
| Agree strongly/agree | 18 (24.0%) | 225 (47.7%) | 16.29, p = 0.001 |
| Neutral | 31 (41.3%) | 147 (31.1%) | |
| Disagree strongly/disagree | 26 (34.7%) | 95 (20.1%) | |
| Missing | 0 (0%) | 5 (1.1%) | |
Bold values indicate statistical significance.