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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Nat Med. 2019 Jul 1;25(8):1260–1265. doi: 10.1038/s41591-019-0493-4

Extended Data Fig 1. PNET subtypes are associated with distinct enhancers of lineage-restricted transcription factors.

Extended Data Fig 1.

(a) H3K27ac, H3K4me2, and mRNA data tracks at ARX and PDX1 in all 8 PNETs from the discovery set and from 2 samples of normal islets of Langerhans (Isl). ChIP-seq signals are scaled by promoter-based DESeq2 normalization (see Methods) and mRNA read counts are normalized by total read numbers (y-axis represents 0–2 fragments per million reads). (b) Distributions of ARX and PDX1 mRNA levels in A- and B-type PNETs. (c) Pearson correlations of H3K27ac signals at PNET type A/alpha-cell and type B/beta-cell enhancers in all 21 tumors from the discovery and validation cohorts (n=8 and n=13 biologically independent samples, respectively).