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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Eur J Pharm Biopharm. 2019 Oct 19;145:76–84. doi: 10.1016/j.ejpb.2019.10.007

Figure 5.

Figure 5.

Microdevices inhibit P-gp transport through biosimilar mucus. Caco-2 cells were grown on transwell membranes for 21 days prior to measurement of R123 flux from the basal to apical chamber in the presence and absence of microdevices (3000 microdevices/cm2) and CSA. The values shown are the cumulative amounts of R123 measured in the apical chamber at specific times (two-way ANOVA, Mean ± SD; ***p<0.0001 w.r.t. untreated control; n=3). Microdevices and CSA both inhibited R123 flux under conditions of a biosimilar mucus layer. Shown is one representative experiment of 3 independent experiments (Supporting Information 7).