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Microdevices increase systemic circulation of R123 in an in vivo mouse model. Oral gavage of microdevices (400,000 devices/kg), CSA, and R123 was performed on C57BL/6 mice where R123 transport was measured over time. A) Systemic R123 amounts measured in serum over time B) Cmax and AUC0–60min values analyzed from the concentration-time curve (two-tailed t-test, Mean ± SD; Cmax p=0.012 Control vs Microdevices; n=8 Control, n=5 CSA, n=8 Microdevices)
