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The effect of Cat-IONP treatment on HIF mRNA expression in 4T1 cell line. (a) HIF1α mRNA expression in 4T1 cultures under hypoxic and normoxic environments. * indicates significant difference between untreated and catalase or Cat-IONP treated groups (p < 0.05). (b) HIF2α mRNA expression in 4T1 cultures under hypoxic and normoxic environments. ** indicates significant difference between untreated and catalase or Cat-IONP groups (p < 0.001).
