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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Biol Psychiatry. 2019 Apr 8;86(5):365–376. doi: 10.1016/j.biopsych.2019.03.984

Table 3.

Significant eQTLs observed with respect to the GWS variants identified in trans-ancestry meta-analysis considering 13 CNS tissues. TSS: transcription start site.

rsID Gene TSS distance slope se P value FDR Q Top CNS Tissue
rs1360983 FGF14-AS2 −178872 −0.361 0.078 2.00E-05 1.72E-04 Spinal cord (cervical c-1)
rs61667602 LRRC37A2 −803528 1.169 0.063 2.29E-36 4.69E-34 Cerebellum
LRRC37A4P 157648 −1.096 0.061 4.20E-34 7.89E-32 Nucleus accumbens (basal ganglia)
AC005829.1 −559054 1.132 0.068 1.67E-32 2.18E-30 Cerebellum
KANSL1-AS1 −485593 1.202 0.072 3.39E-32 4.05E-30 Cortex
AC005829.2 −552623 1.219 0.076 2.65E-31 2.45E-29 Cerebellum
PLEKHM1 217234 −0.951 0.062 7.95E-30 5.43E-28 Cerebellum
ARL17A −871739 1.130 0.076 5.96E-29 3.80E-27 Cerebellum
MAPK8IP1P2 105643 1.093 0.083 5.77E-25 2.30E-23 Cerebellum
MAPK8IP1P1 −535623 1.157 0.085 1.25E-24 4.78E-23 Cerebellar Hemisphere
DND1P1 122112 1.166 0.096 3.14E-22 9.89E-21 Cortex
LINC02210 87655 0.690 0.059 3.02E-21 8.66E-20 Cortex
SPPL2C −136907 0.734 0.067 8.67E-20 2.18E-18 Cerebellum
LRRC37A −584750 1.004 0.093 3.42E-19 7.91E-18 Cerebellum
AC091132.1 204723 −0.922 0.098 4.67E-16 7.83E-15 Cerebellum
FAM215B −854812 0.844 0.090 6.89E-16 1.14E-14 Cerebellum
FMNL1 485759 −0.672 0.074 2.54E-15 3.87E-14 Cerebellum
AC091132.3 176406 0.757 0.120 6.44E-09 6.76E-08 Cerebellar Hemisphere
ARHGAP27 273562 0.459 0.078 4.94E-08 4.93E-07 Nucleus accumbens (basal ganglia)
AC091132.2 255139 −0.573 0.101 1.03E-07 1.00E-06 Cerebellum
AC008105.3 486194 −0.469 0.086 3.15E-07 2.99E-06 Cerebellum
MAPT-AS1 −187617 0.508 0.096 6.23E-07 5.72E-06 Cerebellum
MAPT −186399 −0.316 0.065 3.62E-06 3.22E-05 Cerebellum
CRHR1 86082 −0.399 0.098 1.01E-04 8.31E-04 Putamen (basal ganglia)
RPS26P8 99440 0.698 0.169 1.11E-04 9.12E-04 Spinal cord (cervical c-1)
KANSL1 −517384 0.355 0.090 1.42E-04 0.001 Cerebellum
NMT1 656319 −0.211 0.057 3.44E-04 0.003 Cerebellum
NSF −882686 −0.158 0.043 3.93E-04 0.003 Cerebellum
AC008105.1 466248 −0.247 0.072 7.87E-04 0.006 Cerebellum
AC091132.4 162179 −0.387 0.118 0.001 0.010 Cerebellum
AC015936.1 760069 0.575 0.173 0.002 0.011 Spinal cord (cervical c-1)
CR936218.1 −327330 −0.393 0.122 0.002 0.013 Putamen (basal ganglia)
ACBD4 575382 −0.175 0.057 0.003 0.020 Cerebellum
PLCD3 574628 0.189 0.067 0.006 0.041 Hypothalamus
ARL17B −653781 0.351 0.127 0.007 0.043 Cerebellum
rs2291317 BIN3 −699499 0.212 0.074 0.005 0.034 Nucleus accumbens (basal ganglia)
FAM160B2 −119533 0.251 0.089 0.007 0.043 Substantia nigra