Table 3. Mechanism of inhibition studies results.
| DPAP1 | CatC | FP3 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SMDC # | Model | Ki (μM) | α | β | Model | Ki (μM) | α | β | Model | Ki (μM) | α | β |
| 112054 | COM | 0.44 (0.07) | = ∞ | 0 < β < ∞ | N.D. | N.D. | ||||||
| 97214 | COM | 3.0 (0.3) | = ∞ | 0 < β < ∞ | N.D. | N.D. | ||||||
| 31843 | P-C | 6.2 (0.9) | 5.6 (0.7) | = 1 | P-M | 140 (50) | 0.33 (0.06) | 0 (0.04) | UNC | 14.2 (0.1) | N.A. | |
| 103222 | P-C | 1.1 (0.2) | 2.12 (0.09) | = 1 | N.D. | UNC | 9.1 (0.6) | N.A. | ||||
| 168313 | P-C | 4.1 (0.6) | 2.8 (0.2) | = 1 | N.D. | N.D. | ||||||
| 170136 | P-C | 1.4 (0.3) | 2.3 (0.1) | = 1 | P-NC | 0.8 (0.2) | = 1 | 0.56 (0.02) | P-U | 12 (4) | 0.07 (0.02) | |
| 170156 | N.D. | P-NC | 3.7 (0.9) | = 1 | 0.52 (0.04) | N.D. | ||||||
| 178790 | P-C | 0.40 (0.07) | 2.7 (0.2) | = 1 | N.D. | N.D. | ||||||
| 178801 | P-C | 0.36 (0.06) | 3.2 (0.2) | = 1 | N.D. | P-M | 6.6 (2.5) | 0.22 (0.09) | 0.09 (0.03) | |||
| 170123 | P-M | 1.3 (0.4) | 4.3 (1.3) | 1.4 (0.3) | P-NC | 0.95 (0.3) | = 1 | 0.66 (0.03) | P-M | 3.8 (0.9) | 0.38 (0.09) | 0.23 (0.03) |
| 106517 | P-M | 1.0 (0.3) | 1.3 (0.2) | 0.85 (0.05) | N.D. | N.D. | ||||||
| 153437A | P-M | 0.06 (0.02) | 4.0 (1.5) | 0.35 (0.05) | P-M | 2.4 (1) | 2.6 (0.6) | 1.7 (0.1) | N.D. | |||
Inhibition models: COM, competitive (Eq 3); UNC, uncompetitive (Eq 4); P-M, partial mixed (Eq 9); P-C, partial competitive (Eq 6); P-NC, partial non-competitive (Eq 8); P-U, partial uncompetitive (Eq 7). N.D., Not determined; N.A. Not Applicable. Standard errors of the fit for each parameter are shown in parentheses.