Table 1. Binding kinetics of SYNT001 to human and primate FcRn at different pH values.

pFcRn, cynomolgus monkey FcRn.

Type of FcRn	Ka (104/Ms)	Kd (10−4/s)	KD (nM)*
pH 7.4
hFcRn	35.6 ± 0.3	2.93 ± 0.08	1.19 ± 0.06
pFcRn	4.7 ± 0.1	5.6 ± 0.0	11.9
pH 6.0
hFcRn	43.6 ± 1.6	2.71 ± 0.56	0.87 ± 0.2
pFcRn	2.2 ± 0.2	5.1 ± 0.4	23.2

*The kinetic rate constants were obtained using a simple first-order (1:1) Langmuir bimolecular interaction model. The kinetic values represent the average of duplicates.