Table 4. TEAEs by preferred term—safety population.

Note that each individual was only counted once per preferred term.

Preferred term	Vehicle (n = 8)	SYNT001 (1 mg/kg) (n = 6)	SYNT001 (3 mg/kg) (n = 6)	SYNT001 (10 mg/kg) (n = 6)	SYNT001 (30 mg/kg) (n = 5)	Pooled SYNT001 (n = 23)
Individuals with ≥1 TEAE, n (%)	1 (12.5)	0	0	3 (50.0)	5 (100)	8 (34.8)
Headache	0	0	0	3 (50.0)	5 (100)	8 (34.8)
Chills	1 (12.5)	0	0	0	1 (20.0)	1 (4.3)
Presyncope	0	0	0	1 (16.7)	0	1 (4.3)
Fatigue	0	0	0	1 (16.7)	0	1 (4.3)
Pyrexia	0	0	0	1 (16.7)	0	1 (4.3)
Abdominal pain	0	0	0	0	1 (20.0)	1 (4.3)
Diarrhea	0	0	0	0	1 (20.0)	1 (4.3)
Nausea	0	0	0	0	1 (20.0)	1 (4.3)
Arthralgia	0	0	0	1 (16.7)	0	1 (4.3)
Muscular weakness	0	0	0	1 (16.7)	0	1 (4.3)
Myalgia	0	0	0	1 (16.7)	0	1 (4.3)
Lacrimation increased	0	0	0	1 (16.7)	0	1 (4.3)
Decreased appetite	0	0	0	0	1 (20.0)	1 (4.3)
Rhinorrhea	0	0	0	1 (16.7)	0	1 (4.3)