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. 2019 Nov 6;28:101373. doi: 10.1016/j.redox.2019.101373

Fig. 5.

Fig. 5

IL-35 and IL-10 do not reverse LPC-induced upregulation of trained immunity signature enzymes in HAECs. HAECs were treated with LPC (10 μM), with or without IL-35/IL-10 (10 ng/mL) for 18 h, RNA sequencing (RNA-Seq) experiments were performed. A & B. Gene set enrichment analysis (GSEA) plots showing that glycolysis and cholesterol homeostasis pathways are upregulated by LPC in HAECs. C. Representative gene expression changes by LPC, IL-35, and IL-10. D & E. GSEA plots showing that glycolysis and cholesterol homeostasis pathways are not affected by IL-35 in HAECs. F & G. GSEA plots showing that glycolysis and cholesterol homeostasis pathways are not changed by IL-10 in HAECs. H. Representative gene expression changes by LPC, IL-35, and IL-10. NES, normalized enrichment score.