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Time-course for changes in (A) systolic blood pressure, systolic blood pressure, and (B) heart rate in rats administered with nicotine and irbesartan for 4 weeks. All values are given as mean ± SEM for n = 13–14/group; *P < 0.05 for vehicle vs. nicotine (NIC) group; and # P < 0.05 for NIC vs. NIC+Irb group using two-way ANOVA with Tukey post-hoc test.
