Table 2.
End-point analysis of body weight, organ weights, and plasma cotinine.
| Parameters | Vehicle (n = 13) | NIC (n = 14) | NIC+Irb (n = 14) |
|---|---|---|---|
| Body weight (g) | 296 ± 17 | 280 ± 15 | 294 ± 121 |
| Heart weight (mg) | 1,001 ± 28 | 1,267 ± 63* | 1,073 ± 61† |
| Atria weight (mg) | 34 ± 7 | 29 ± 5 | 36 ± 6 |
| LV weight (mg) | 510 ± 39 | 686 ± 50* | 523 ± 54† |
| RV weight (mg) | 188 ± 15 | 181 ± 18 | 190 ± 16 |
| Lung weight (mg) | 1,188 ± 93 | 1,467 ± 86 | 1,297 ± 110 |
| Tibia length (mm) | 44 ± 3 | 43 ± 2 | 42 ± 3 |
| HW : TL (mg/mm) | 22.7 ± 0.6 | 29.5 ± 1.5* | 25.6 ± 1.4† |
| LV : TL (mg/mm) | 11.9 ± 1.4 | 16.1 ± 1.1* | 12.3 ± 0.6† |
| LW : TL (mg/mm) | 27.0 ± 2.1 | 34.1 ± 2.0 | 30.9 ± 2.6 |
| Cotinine (ng/ml) | – | 169 ± 21 | 142 ± 24 |
All values are given as mean ± SEM for n = 14-15/group; *p < 0.05 for control vs. NIC group; and †p < 0.1 for NIC vs. NIC+Irb group using one way ANOVA with Tukey post-hoc test. HW, heart weight; LV, left ventricle; LW, lung weight; RV, right ventricle; TL, tibia length.