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. 2019 Nov 16;31:85–97. doi: 10.1016/j.molmet.2019.11.008

Figure 7.

Figure 7

Purβ promotes Adcy6 expression. Primary hepatocytes were infected with Scramble or shPURB1 adenoviruses for 30 h or infected with βGal or Purβ adenovirus overnight. Total RNA was isolated, and RNA-seq was performed. (A) Heat map of PDEs in Purβ-overexpressing and PurβKD hepatocytes. (B) Heat map of ADCYs in Purβ-overexpressing and PurβKD hepatocytes. (C) ADCY6 mRNA and protein levels in Purβ-overexpressing hepatocytes (n = 4). (D) ADCY6 mRNA and protein levels in PurβKD hepatocytes (n = 4). (E) ADCY6 mRNA and protein levels in PurβKD and control db/db mice (n = 7–8). (F) ADCY6 mRNA and protein levels in fasted or fed mice (n = 6). (G–H) ADCY6 mRNA and protein levels in the livers of HFD or ob/ob mice (n = 6–8). *p < 0.05. **p < 0.01.