Table 2.
Representation of the aberrated regions detected in the present study (CanFam3.1 annotation), showing a correspondent canine or human syntenic region in other studies, which are indicated through the bibliographic number: Wong et al. (8), Poorman et al. (24), Giannuzzi et al. (27), Hendricks et al. (28), Hayward et al. (6), Curtin et al. (5), Lyu et al. (7), and Furney et al. (4). CNAs are listed on the base of the chromosomal location, and divided into 3 groups: (A) gained regions with a penetrance ≥25% (GR25); (B) lost regions with a penetrance ≥25% (LR25); (C) represents gained regions found statistically significant by Gistic analysis (GS).
| CANINE studies | HUMAN studies | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | Present study | Wong et al. (8) | Poorman et al. (24) | Giannuzzi et al. (27) | Hendricks et al. (28) | Wong et al. (8) | Poorman et al. (24) | Hayward et al. (6) | Curtin et al. (5) | Lyu et al. (7) | Furney et al. (4) |
| (A) GR25 | |||||||||||
| 10 | 7814333–7827061 | V | |||||||||
| 7827061–7896552 | V | ||||||||||
| 7896552–8860169 | V | ||||||||||
| 8860169–8889136 | V | ||||||||||
| 8889136–9197582 | V | ||||||||||
| 9225870–9593296 | V | ||||||||||
| 9593296–9724425 | V | ||||||||||
| 9724425–9752955 | V | ||||||||||
| 13 | 1722286–32543593 | V | V | V | V | ||||||
| 32543593–34917864 | V | V | |||||||||
| 34917864–60030824* | V | V | |||||||||
| V | V | ||||||||||
| 60030824–60110727 | V | ||||||||||
| 30 | 16069762:16221290 | V | V | ||||||||
| 16221290:16599297 | V | V | |||||||||
| 16599298:16724522 | V | ||||||||||
| 16724522:16973676 | V | ||||||||||
| 16973676:17914975 | V | ||||||||||
| (B) LR25 | |||||||||||
| 11 | 38095457–38199500 | V | |||||||||
| 38199500–38219624 | V | ||||||||||
| 38219624–38219683 | V | ||||||||||
| 38219683–38263483 | V | ||||||||||
| 38263483–38372087 | V | ||||||||||
| 22 | 102563–10473893 | V | |||||||||
| 30 | 1305764–2530849 | V | |||||||||
| 2530849–2552538 | V | ||||||||||
| 2552538–2770691 | V | ||||||||||
| 2770691–4634866 | V | ||||||||||
| 4634866–5314049 | V | ||||||||||
| 5314049–9109654 | V | ||||||||||
| (C) GS | |||||||||||
| 9 | 1839468–1890597 | V | |||||||||
| 2038907–2071775 | V | ||||||||||
| 10 | 6204314–9752896 | V | |||||||||
| 9948113–10047999 | V | ||||||||||
| 13 | 101–23829651 | V | V | V | |||||||
| 23906345–60168042* | V | V | V | ||||||||
| V | |||||||||||
Canine regions marked with * were syntenic to human regions belonging to two different chromosomes, and were split accordingly (view Table 3 for details).