Figure 1.

The scheme of m⁶A RNA methylation. m⁶A RNA methylation is regulated by “writers”, “erasers,” and “readers”. METTL3, methyltransferase-like 3; METTL14, methyltransferase like 14; WTAP, Wilms tumor 1-associated protein; RBM15, RNA binding motif protein 15; ZC3H13, zinc finger CCCH-type containing 13; VIRMA, vir like m6A methyltransferase associated; FTO, the fat mass and obesity-associated protein; ALKBH5, alkB homolog 5; YTH, YT521-B homology domain-containing protein; eIF3, eukaryotic translation initiation factor 3; IGF2BP, IGF2 mRNA binding proteins; HNRNP, heterogeneous nuclear ribonucleoprotein.