Table 1.
Expression, clinical significance, and biological function of METTL3 in various cancers.
| Cancer type | Expression | Role | Biological function | References |
|---|---|---|---|---|
| Bladder cancer | Upregulated | Oncogene | Proliferation, invasion, tumorigenesis | (28–30) |
| / | Tumor suppressor | Proliferation | (31) | |
| Renal cell carcinoma | Downregulated | Tumor suppressor | Proliferation, migration, invasion, cell cycle | (32) |
| Upregulated | Tumor suppressor | Proliferation, migration | (22) | |
| Lung cancer | Upregulated | Oncogene | Proliferation, invasion, migration | (33–36) |
| Colorectal cancer | Upregulated | Oncogene | Stem cell differentiation, migration, tumorigenesis | (34, 37, 38) |
| / | Tumor suppressor | Proliferation, migration, invasion | (26) | |
| Glioma | Upregulated | Oncogene | Proliferation | (39) |
| / | Tumor suppressor | Proliferation, stem cell differentiation | (40) | |
| Breast cancer | Upregulated | Oncogene | Proliferation, apoptosis, migration | (41, 42) |
| Downregulated | Tumor suppressor | Cell viability and colony formation | (43) | |
| Leukaemic | Upregulated | Oncogene | Proliferation, cell cycle, tumorigenesis, stem cell differentiation | (44, 45) |
| Osteosarcoma | Upregulated | Oncogene | Proliferation, migration, invasion | (46) |
| Gastric cancer | Upregulated | Oncogene | Proliferation, migration, invasion | (23, 47, 48) |
| Melanoma | Upregulated | Oncogene | Colony formation, invasion | (49) |
| Ovarian carcinoma | Upregulated | Oncogene | Proliferation, motility, invasion, tumorigenesis | (50) |
| Hepatocellular carcinoma | Upregulated | Oncogene | Proliferation, migration, colony formation, tumorigenesis | (51) |
| Pancreatic cancer | / | Oncogene | Chemoresistance | (25) |
METTL3, methyltransferase like 3.