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. 2019 Nov 13;19:179–189. doi: 10.1016/j.omtn.2019.10.036

Figure 3.

Figure 3

miR-381-3p Directly Targets the 3′ UTR of ETS2 mRNA

(A) miRNAs binding to ETS2 predicted by Targetscan and DIANA TOOLS. (B) Expression of miR-381-3p and ETS2 in BALF neutrophils in ARDS mouse models and mice in the control group examined by qRT-PCR (*p < 0.05 versus the control group). (C) Binding sites of miR-381-3p to ETS2 predicted by Targetscan. (D) Binding of miR-381-3p and ETS2 verified by the dual-luciferase reporter assay (*p < 0.05 versus the agomir-NC group). (E) Expression of ETS2 in BALF neutrophils of ARDS mouse models examined by qRT-PCR (*p < 0.05 versus the agomir-NC group). (F) Expression of ETS2 in neutrophils of BALF from ARDS mouse models examined by western blot analysis (*p < 0.05 versus the agomir-NC group). The measurement data are presented as mean ± SD. Comparison between two groups was analyzed by an unpaired t test. n = 8. The cell experiments were repeated three times.