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NF-κB Signaling Pathway
(Left) Canonical pathway of NF-κB activation. This pathway is mediated by the IκB kinase (IKK) complex, leading to phosphorylation and degradation of IκB. (Right) Non-canonical pathway of NF-κB activation. This pathway involves IKKα activation via NF-κB-inducing kinase (NIK) and induces the phosphorylation of p100, leading to the generation and translocation of p52.
