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. 2019 Nov 21;31:124–137. doi: 10.1016/j.molmet.2019.11.004

Figure 1.

Figure 1

Circadian GLP-1 secretion is dependent on the core clock gene Bmal1. (A-B) OGTTs were conducted on 4-hour fasted C57Bl/6J mice at six time points throughout a 24-hour light (open bars)-dark (closed bars) cycle (ZT0 = 06:00), with individual plots for each time point represented in (A) and the 24-hour ΔAUC profile represented in (B). (C-D) OGTTs were performed on 4-hour fasted Bmal1 WT and KO mice at ZT2 and ZT14 with individual plots for each time point shown in (C) and the ΔAUC of each timepoint represented in (D). (A and C) t0 indicates the absolute fasting values for GLP-1 in pg/ml. n = 4–8 mice for all time points in all of the experiments. *p < 0.05.