Figure 2.

Identification of potential targets regulating circadian GLP-1 secretion. (A) Heat maps of GO transport vesicle and (B) selected L-cell secretory genes identified by microarray in synchronized the mGLUTag L-cells showing log₂ fold-change between the two time points, 4 and 16 h (n = 3 for each time point). (C) Volcano plot of the mass spectrometry results of the synchronized mGLUTag L-cells at peak (8 h) and trough (20 h) of GLP-1 secretion (n = 3 for each time point). SCGN is indicated by the open circle. (D) Pathway enrichment analysis of protein clusters that were up regulated at each time point, with SCGN identified under the secretory granules cluster.