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. 2019 Dec 18;9:19330. doi: 10.1038/s41598-019-55885-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TH expression in the substantia nigra. (A) On the top: representative fluorescent IHC images of TH⁺ neurons (red) and nuclei (blue) immunolabeling in the SNpc. (1–2) WT + BSS (n = 4); (3–4) B4galnt1^+/− + BSS, (n = 4) (5–6) B4galnt1^+/− + OligoGM1, n = 4). On the bottom: quantification of the TH⁺ neurons normalized on nuclei area (n = 4 for group; 8–10 brain/sections animal). Data are expressed as mean ± SEM (F_(2,32) = 17.26, ****p < 0.001 B4galnt1^+/− + BSS compared with WT and B4galnt1^+/− + OligoGM1; one-way ANOVA followed by Bonferroni’s multiple comparisons test). (B) On the left: representative immunoblotting images of TH and calnexin are shown after cropping (full length images of blot are presented as Supplementary Fig. S8). On the right: Semi-quantitative analysis of nigral TH expression related to calnexin level (n = 4). Data are expressed as fold increase or decrease over the control (WT) of the mean ± SEM (F_(2,8) = 10.34, **p < 0.01 B4galnt1^+/− + BSS compared with WT and B4galnt1^+/− + OligoGM1; one-way ANOVA followed by Bonferroni’s multiple comparisons test).