Figure 2.

Effect of TLR4 blockade on T lymphocytes in NOD mice after treatment with CLI-095: (A) Expression of CD25 on CD4+ T lymphocytes from the pancreatic lymph nodes (PLN), inguinal lymph node (ILN) and from the spleen of the treated mice (grey) and the controls (black). (B) %Ki67+CD4+ T lymphocytes in the different lymphoid organs. (C) %IFNγ+CD4+ T lymphocytes in the different lymphoid organs. (D) %Ki67+CD8+ T lymphocytes in different lymphoid organs. (E) %IFNγ+CD8+ T lymphocytes in different lymphoid organs. Data are means ± SEM collected from five mice *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001