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. 2019 Dec 18;9:19350. doi: 10.1038/s41598-019-55521-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Insulitis score in 12-week female NOD mice. (A) Representative histological images of insulitis score. 0: no infiltration. 1: peri-insulitis. 2: infiltrative insulitis <50% of the islet. 3: infiltrative insulitis >50% of the islet. (B) Insulitis score. Female NOD mice were treated with vehicle, 0.1 mg/kg, 0.3 mg/kg or 1 mg/kg CLI-095. Data are collected from 50–60 islets from the pancreas of every mice (three mice in every condition). Every islet was analysed blindly and every islet was given a score between 0 and 3.