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. 2019 Dec 18;9:19360. doi: 10.1038/s41598-019-55712-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pulmonary tissue inflammation in triple-disease model. Haematoxylin and eosin stained sections representative of naïve mice and mice in each experimental group (top) were used to quantify parameters of lung damage (bottom). Data are representative of one study from two independent studies collected at 3 days post Spn infection. n = 5–7 mice in each group. Data were analysed by Mann-Whitney test against the direct control group for each experimental condition. *P < 0.05, **P < 0.01 and ***P < 0.001.