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. 2019 Dec 18;9:19402. doi: 10.1038/s41598-019-55294-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Absolute rotations during amphetamine elicited behavioral testing. Behavioral testing was performed after completion of MPTP lesioning, prior to the start of experimental procedures (pre-treatment) and 8 weeks after the last experimental procedure (post treatment). Pre-treatment MPTP only mice (n = 14) were separated into two cohorts that made up the post-treatment MPTP only (n = 7) and the IN+FUS groups (n = 7). FUS only group were treated taken from a separate cohort of MPTP mice (n = 6). Within each group, clockwise (CW) and counterclockwise (CCW) rotations were compared, with significant differences between CW and CCW rotation found only in the IN+FUS group (two-tailed paired Student’s t-test). Error bars represent standard error mean. * - p < 0.05, ns – not significant (p > 0.05).