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. 2019 Dec 18;9:19227. doi: 10.1038/s41598-019-55851-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Graphical modelling of factors used for the multivariable analyses. Line thickness is proportional to the number of patients that contributed to the comparison. Green lines indicate a positive relationship, and red lines indicate a negative relationship. Abbreviations: mci, mild cognitive impairment; apo, apolipoprotein E ε4 carrier; wmh, white matter hyperintensity; en1, enterotype I; age, patient’s age; smk, smoking habit; cmb, cerebral microbleeds.