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. 2019 Dec 18;10:5765. doi: 10.1038/s41467-019-13544-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Sex-specific genetic correlations of body composition traits (n = up to 155,961) and physical activity (n = up to 66,224) with sex-combined psychiatric disorders (n = up to 77,096) and behavioural traits (n = up to 157,355). The autosomal genetic correlations were calculated by bivariate linkage disequilibrium score regression (LDSC). Coloured bars represent genetic correlations, error bars depict standard errors (s.e.) and asterisks indicate statistically significant genetic correlations with p values less than α = 0.0003. This threshold was calculated via the identification of the number of independent tests using matrix decomposition of the genetic correlation matrix and subsequent Bonferroni correction of α = 0.05 for 190 independent tests. ADHD = attention-deficit/hyperactivity disorder, BF% = body fat percentage, FFM = fat-free mass, FM = fat mass, PA = physical activity.