Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 18;9:19388. doi: 10.1038/s41598-019-56045-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Immunofluorescence studies of non-stenotic and stenotic intestinal tissue of Crohn’s disease patients. (A) Cryostat sections of 30 surgical resection specimen of stenotic and non-stenotic intestinal tissue of 15 Crohn’s disease patients were stained with markers of fibrosis (Collagen I, Collagen V and Tenascin). Depicted is the submucosal tissue of non-stenotic (left) and stenotic bowel tissue (right). (B–D) Fibrosis markers were detectable in both, non-stenotic and stenotic bowel tissue; however, Collagen I, Collagen V and Tenascin were significantly elevated in stenotic compared to non-stenotic tissue in the “overall”- (all p < 0.001) and the “per-bowel-wall-layer”-analysis (all p < 0.02; except for mucosal Tenascin fluorescence intensity which did not significantly differed between stenotic and non-stenotic tissue). Data are mean ± standard error of mean (SEM). Statistical analysis was performed using Mann-Whitney U test. Two-sided p values < 0.05 were considered statistically significant.